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Updated: May 21, 2026
10:36
Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
Estrogen receptors and human disease: an update
Katherine A Burns1, Kenneth S Korach
1Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Archives of Toxicology
|June 1, 2012
Summary
Estrogens and their receptors (ERs) influence many mammalian physiological processes. This review updates the literature on estrogen
Area of Science:
- Endocrinology
- Oncology
- Cardiovascular Science
Background:
- Estrogens and estrogen receptors (ERs), ERα and ERβ, play critical roles in mammalian physiology.
- Estrogen's involvement in numerous diseases is well-established, necessitating updated research.
- Previous reviews highlighted estrogen's broad impact, requiring a current literature assessment.
Purpose of the Study:
- To provide a 5-year literature update on the influence of estrogens on human diseases.
- To focus on estrogen's role in specific cancers, endometriosis, fibroids, and cardiovascular disease.
- To synthesize recent findings primarily from human data and clinical trials.
Main Methods:
- Literature review focusing on articles published after 2006.
- Analysis of experimental studies providing insights into human disease.
- Emphasis on human data and clinical trials for disease state evaluation.
Main Results:
- Estrogen action through ERα and/or ERβ mediates various human disease states.
- Updated literature confirms estrogen's influence on breast, ovarian, colorectal, prostate, and endometrial cancers.
- Estrogen's role in endometriosis, fibroids, and cardiovascular disease progression is further elucidated.
Conclusions:
- Estrogen signaling via ERs is a significant factor in the pathogenesis and progression of multiple human diseases.
- Recent research reinforces the need to consider estrogen's complex role in disease management.
- Further investigation into estrogen's therapeutic targeting in these conditions is warranted.
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