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Updated: May 21, 2026
08:24
Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins
Published on: November 18, 2016
Widespread epithelioid angiosarcoma with ventricular wall involvement in a dog
A Gázquez1, J Martín de Las Mulas, Y Millán Ruiz
1Department of Animal Medicine, Veterinary Faculty, Extremadura University, Cáceres, Spain.
Histology and Histopathology
|June 1, 2012
Summary
This study details a rare canine epithelioid angiosarcoma, a fast-spreading cancer. The Cocker Spaniel case highlights the aggressive nature of this undifferentiated metastasizing tumor in dogs.
Area of Science:
- Veterinary Pathology
- Canine Oncology
Background:
- Reports on a challenging case of canine angiosarcoma, initially presenting as an undifferentiated metastasizing tumor.
- Highlights the diagnostic difficulties associated with poorly differentiated neoplasms in veterinary medicine.
Observation:
- A 14-year-old Cocker Spaniel exhibited rapid deterioration, anorexia, cachexia, and chronic cough.
- Necropsy revealed extensive metastasis with nodules in the heart, lung, liver, and spleen.
- Cytological and histological examinations showed anaplastic epithelioid cells with immunohistochemical evidence of vascular origin (CD31+, Factor VIII-related antigen+).
Findings:
- Diagnosis confirmed as epithelioid angiosarcoma with widespread organ involvement.
- Neoplastic cells expressed CD31 and Factor VIII-related antigen, but not CD18.
- The primary tumor site remained undetermined despite extensive investigation.
Implications:
- Underscores the aggressive behavior and metastatic potential of canine epithelioid angiosarcoma.
- Emphasizes the importance of immunohistochemistry in diagnosing poorly differentiated tumors.
- Suggests the need for further research into the origins and treatment of this canine cancer.
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