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Related Experiment Video

Updated: May 21, 2026

Microparticle Manipulation by Standing Surface Acoustic Waves with Dual-frequency Excitations
06:51

Microparticle Manipulation by Standing Surface Acoustic Waves with Dual-frequency Excitations

Published on: August 21, 2018

Tunable patterning of microparticles and cells using standing surface acoustic waves.

Xiaoyun Ding1, Jinjie Shi, Sz-Chin Steven Lin

  • 1Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.

Lab on a Chip
|June 1, 2012
PubMed
Summary

We developed a novel acoustic-based method to arrange microparticles and cells into patterns within microfluidic channels without fluid flow. This technique offers tunable control over cell patterning, valuable for biological and colloidal research.

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Area of Science:

  • Biotechnology
  • Microfluidics
  • Acoustic manipulation

Background:

  • Microfluidic devices are crucial for biological and colloidal studies.
  • Precise arrangement of microparticles and cells is essential for various applications.
  • Existing patterning methods often rely on fluid flow or are difficult to reconfigure.

Purpose of the Study:

  • To develop a novel acoustic-based technique for tunable microparticle and cell patterning.
  • To demonstrate the ability to create reconfigurable patterns in microfluidic channels.
  • To highlight the advantages of acoustic manipulation for lab-on-a-chip systems.

Main Methods:

  • Utilized pairs of slanted-finger interdigital transducers (SFITs).
  • Generated a tunable standing surface acoustic wave field.

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Last Updated: May 21, 2026

Microparticle Manipulation by Standing Surface Acoustic Waves with Dual-frequency Excitations
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Published on: August 21, 2018

Fabrication and Operation of Acoustofluidic Devices Supporting Bulk Acoustic Standing Waves for Sheathless Focusing of Particles
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Fabrication and Operation of Acoustofluidic Devices Supporting Bulk Acoustic Standing Waves for Sheathless Focusing of Particles

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Fabrication of Surface Acoustic Wave Devices on Lithium Niobate
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Fabrication of Surface Acoustic Wave Devices on Lithium Niobate

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  • Patterned microparticles and cells in one- or two-dimensional arrays without fluidic flow.

    • Main Results:

    • Achieved tunable patterning of microparticles and cells in microfluidic channels.
    • Demonstrated control over cell patterns with up to 72% tunability by adjusting signal frequency.
    • Confirmed non-invasive patterning independent of fluidic flow.

    Conclusions:

    • The developed acoustic-based tunable patterning technique is effective and versatile.
    • This method offers wide tunability, non-invasiveness, and easy integration into lab-on-a-chip systems.
    • The technique holds significant potential for advancing biological and colloidal research.