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Efficient Gene Delivery into Multiple CNS Territories Using In Utero Electroporation
Published on: June 23, 2011
The concept of prenatal gene therapy
Charles Coutelle1, Simon N Waddington
1National Heart and Lung Institute, Molecular and Cellular Medicine Section, Imperial College London, London, UK. c.coutelle@imperial.ac.uk
Abstract:
This introductory chapter provides a short review of the ideas and practical approaches that have led to the present and perceived future development of prenatal gene therapy. It summarizes the advantages and the potential adverse effects of this novel preventive and therapeutic approach to the management of prenatal diseases. It also provides guidance to the range of conditions to which prenatal gene therapy may be applied and to the technical approaches, vectors, and societal/ethical considerations for this newly emerging field of Fetal Medicine.
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