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Strategies for excluding false Y-chromosomal SNP entries from human genome databases
1Department of Forensic Genetics, Institute of Legal Medicine and Forensic Sciences, Berlin, Germany. jessica.rothe@charite.de
Abstract:
Current human genome databases for public single nucleotide polymorphisms (SNPs) still contain a substantial fraction of false entries. The main reasons for errors include sequencing or assembly errors, paralogous sequence-, and private variants. In the course of our studies on the Y chromosome, we established a set of internal laboratory guidelines for reliably identifying false SNP entries in databases.
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