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Published on: June 2, 2014
Bipolar affective disorder and migraine
1Department of Neurology, Fachklinikum Brandis, Am Wald, 04821 Brandis, Germany.
Case Reports in Medicine
|June 1, 2012
Summary
Bipolar disorder and migraine frequently co-occur, particularly in Bipolar II patients. Research explores shared genetic and neuropathological origins, but effective treatments for this comorbidity remain elusive.
Area of Science:
- Neurology
- Psychiatry
Background:
- Comorbidity of bipolar disorder and migraine is prevalent.
- Bipolar II disorder presents a higher risk for comorbid migraine compared to Bipolar I.
Observation:
- Literature review indicates shared genetic and neuropathological underpinnings for both conditions.
- Co-occurrence with other affective disorders and behavioral factors complicate the etiology and progression.
Findings:
- Valproate and topiramate show potential for treating both bipolar disorder and migraine.
- No definitive first-line treatment has been established for the comorbid condition.
Implications:
- Further research is needed to elucidate the common pathophysiology.
- Development of targeted therapies for comorbid bipolar disorder and migraine is a critical unmet need.
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