Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

DNA as a Genetic Template

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

DNA as a Genetic Template

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

From DNA to Protein

From DNA to Protein

The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...

Genome Copying Errors

Genome Copying Errors

DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their survival. Therefore, the copying errors are checked and repaired at three levels.

The Central Dogma

The Central Dogma

The Central Dogma

The Central Dogma

The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A behavioral modulation mechanism involving the phytopathogen Fusarium verticillioides and the stem borer Diatraea saccharalis is conserved in maize.

Communications biology·2026

Same author

Epigenome-wide exploratory study of blood DNA methylation and markers of physical performance indicates subtle differences across levels of cardiovascular fitness.

Frontiers in physiology·2026

Same author

PLANeT: Understanding and leveraging the genome of land plants for a sustainable future.

Cell·2026

Same author

Insect herbivory reshapes rhizosphere bacterial and fungal networks in a stage-specific manner.

Applied and environmental microbiology·2026

Same author

Multi-proteomic profiling indicates potential regulatory signatures underlying rice resistance to Magnaporthe oryzae.

The Plant journal : for cell and molecular biology·2026

Same author

SETD5 dysfunction in human astrocytes drives IL-6-mediated neuronal impairments via the JAK/STAT signaling pathway.

bioRxiv : the preprint server for biology·2026

Search research articles

Related Experiment Video

Updated: May 21, 2026

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

Published on: September 13, 2018

Is a genome a codeword of an error-correcting code?

Luzinete C B Faria¹, Andréa S L Rocha, João H Kleinschmidt

¹Departamento de Telemática, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil. luzinete@dt.fee.unicamp.br

|June 1, 2012

Summary

This summary is machine-generated.

This study provides the first evidence that DNA sequences, including genes and genomes, can be identified as Hamming code codewords, suggesting an underlying error-correcting code in genetic information.

More Related Videos

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

Genome Editing in Mammalian Cell Lines using CRISPR-Cas

Genome Editing in Mammalian Cell Lines using CRISPR-Cas

Published on: April 11, 2019

Related Experiment Videos

Last Updated: May 21, 2026

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

Published on: September 13, 2018

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

Genome Editing in Mammalian Cell Lines using CRISPR-Cas

Genome Editing in Mammalian Cell Lines using CRISPR-Cas

Published on: April 11, 2019

Area of Science:

Genomics
Bioinformatics
Coding Theory

Background:

The structure of DNA as a discrete sequence of four letters raises questions about potential error-correcting codes.
Previous methodologies to detect such codes in DNA have been unsuccessful.

Purpose of the Study:

To investigate if DNA sequences, genes, and genomes can be represented as codewords within specific error-correcting codes.
To provide evidence for the existence of an error-correcting code underlying DNA.

Main Methods:

Identifying DNA sequences as codewords in cyclic error-correcting codes, specifically Hamming codes.
Applying this methodology to complete intron-exon genes and plasmid genomes.

Main Results:

Demonstrated that DNA sequences can be identified as Hamming code codewords.
Extended this identification to complete intron-exon genes and plasmid genomes.

Conclusions:

This research presents the first evidence supporting the hypothesis of an error-correcting code in DNA.
While not definitive proof, the findings suggest a structured, potentially error-correcting nature of genetic sequences.