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A mechanical Turing machine: blueprint for a biomolecular computer.

Ehud Shapiro1

  • 1Department of Computer Science and Applied Math and Department of Biological Chemistry , Weizmann Institute of Science , Rehovot 76100 , Israel.

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Researchers built a mechanical universal computer based on Alan Turing's design. This programmable device uses molecular-like actions, suggesting a potential biomolecular computer for in vivo applications.

Keywords:
Turing machinebiomolecular computercomputing device

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Area of Science:

  • Biomolecular engineering
  • Theoretical computer science
  • Mechanical engineering

Background:

  • Alan Turing proposed a theoretical universal computing machine.
  • Biomolecular machines in cells perform complex operations.
  • Existing technology lacks programmable in vivo computation.

Purpose of the Study:

  • To describe a working mechanical device embodying Turing's universal computer.
  • To explore the feasibility of a biomolecular implementation.
  • To highlight potential pharmaceutical and biological applications.

Main Methods:

  • Utilizing three-dimensional building blocks.
  • Employing mechanical analogues of polymer elongation, cleavage, ligation, and movement.
  • Leveraging molecular recognition for allosteric conformational changes.

Main Results:

  • A functional mechanical universal programmable computer has been developed.
  • The device's operations are analogous to cellular biomolecular machines.
  • A biomolecular embodiment is considered feasible.

Conclusions:

  • The mechanical device demonstrates a programmable computer using biomolecular principles.
  • A biomolecular version could operate in vivo, computing and releasing synthetic biopolymers.
  • This technology holds promise for pharmaceutical and biological applications.