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Updated: May 21, 2026

Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex
Published on: August 2, 2021
Life and Death Decisions in the CD95 System: Main Pro-and Anti-Apoptotic Modulators
Inna N Lavrik1, Peter H Krammer
1Division of Immunogenetics, Tumorimmunology Program German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
Abstract:
Apoptosis is common to all multicellular organisms. Apoptosis can be triggered by the extrinsic (death receptor (DR)) or the intrinsic (mitochondrial) death pathways. CD95 (APO-1/Fas) is a prototypic member of the DR family. This review is focused on the mechanisms of CD95 (APO-1/Fas)-mediated apoptosis and the role in the apoptosis of the death effector domain (DED)-containing proteins: pro-apoptotic protein procaspase-8 and anti-apoptotic protein c-FLIP. Gaining insights into these processes will improve our understanding of the pathogenesis of diseases such as cancer, autoimmunity and AIDS, and will open new approaches to rational treatment strategies.
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