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06:09

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Antibiotic resistance of uropathogens in newborns and young children with acute pyelonephritis

Amira Peco-Antić1, Dusan Paripović, Svetlana Buljugić

  • 1School of Medicine, University of Belgrade, Belgrade, Serbia. amira@udk.bg.ac.rs

Srpski Arhiv Za Celokupno Lekarstvo
|June 2, 2012
PubMed

Insights

Newborns exhibit higher antimicrobial resistance to common antibiotics compared to older children with acute pyelonephritis. This escalating resistance in pediatric urinary tract infections is a significant clinical concern.

Area of Science:

  • Pediatric infectious diseases
  • Antimicrobial resistance
  • Urology

Background:

  • Urinary tract infections (UTIs) are prevalent in children, categorized as acute cystitis or acute pyelonephritis based on severity and complications.
  • Acute pyelonephritis, a kidney infection, requires careful monitoring due to potential long-term consequences.

Purpose of the Study:

  • To evaluate antimicrobial resistance patterns of uropathogens in newborns and young children diagnosed with acute pyelonephritis over a five-year period.
  • To identify trends in resistance to commonly prescribed antibiotics.

Main Methods:

  • Retrospective analysis of uropathogen resistance to 11 common antimicrobial agents.
  • Study included newborns and young children treated for acute pyelonephritis between 2005 and 2009.
  • Antibacterial susceptibility testing was performed using the standard disc diffusion method.

Main Results:

  • Escherichia coli was the predominant pathogen (85.5%).
  • Newborns demonstrated significantly higher antimicrobial resistance compared to children over one month old.
  • Multidrug resistance was more prevalent in newborns during the earlier study period (2005-2007).

Conclusions:

  • Newborns present a higher incidence of antimicrobial resistance in acute pyelonephritis cases than older children.
  • The increasing trend of antimicrobial resistance in pediatric acute pyelonephritis is a critical public health issue.
Abstract

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