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Unconsciousness associated with midazolam and erythromycin
A Hiller1, K T Olkkola, P Isohanni
1Department of Anaesthesia, Otolaryngological Hospital, Helsinki University Central Hospital, Finland.
British Journal of Anaesthesia
|December 1, 1990
Summary
Erythromycin significantly increased midazolam plasma concentrations in a child, leading to loss of consciousness. This suggests erythromycin may inhibit midazolam metabolism, increasing risks during co-administration in pediatric patients.
Area of Science:
- Pharmacology
- Pediatric Anesthesiology
Background:
- Midazolam is commonly used for procedural sedation in children.
- Erythromycin is an antibiotic with known drug-drug interaction potential.