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Updated: May 21, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Knowledge translation of research findings
Jeremy M Grimshaw1, Martin P Eccles, John N Lavis
1Department of Medicine, Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, 501 Smyth Road, Box 711, Ottawa, ON, K1H 8L6, Canada. jgrimshaw@ohri.ca
Bridging the evidence-practice gap requires effective knowledge translation (KT). This involves tailoring research findings into accessible formats for healthcare professionals and consumers, informed by barrier assessments.
Area of Science:
- Health Services Research
- Knowledge Translation
- Evidence-Based Practice
Background:
- Persistent gaps exist between research findings, clinical practice, and health policy.
- These evidence-practice gaps hinder optimal patient benefit and increase healthcare costs.
- International focus is increasing on strategies to reduce these translation gaps.
Purpose of the Study:
- To summarize current concepts and evidence for guiding knowledge translation (KT) activities.
- To address key questions: what, to whom, by whom, how, and with what effect knowledge should be transferred.
- To define KT as T2 research: translating new clinical knowledge into improved health outcomes.
Main Methods:
- The study synthesizes existing evidence and concepts related to knowledge translation.
- It structures the discussion around five core questions guiding KT activities.
- It reviews systematic reviews on interventions for healthcare professionals and consumers.
Main Results:
- Up-to-date systematic reviews are recommended as the primary unit for knowledge translation.
- Effective KT requires identifying key messages and tailoring them for diverse audiences.
- KT strategies should be informed by assessments of barriers and facilitators to research use.
Conclusions:
- A substantial evidence base exists for KT targeting healthcare professionals and consumers.
- Evidence for KT approaches aimed at policymakers and senior managers is less robust.
- Innovative KT approaches for policymakers require further evaluation.
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