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Related Concept Videos

Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Pre-mRNA Processing: RNA Splicing01:32

Pre-mRNA Processing: RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Point and Frameshift Mutations01:30

Point and Frameshift Mutations

Point mutations are genetic alterations involving the change of a single nucleotide base pair in DNA. Depending on how the alteration affects protein synthesis, they can lead to various consequences.Point mutations fall into the following types:Silent mutations occur when a nucleotide change does not alter the amino acid sequence due to the redundancy of the genetic code. For instance, changing ACC to ACA still encodes threonine, leaving the protein function unaffected. This occurs because...

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Related Experiment Video

Updated: May 21, 2026

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
08:35

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

Published on: June 24, 2021

VERSE: a varying effect regression for splicing elements discovery.

Jing Zhang1, C-C Jay Kuo, Liang Chen

  • 1Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, CA, USA.

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
|June 2, 2012
PubMed
Summary
This summary is machine-generated.

Researchers developed VERSE, a novel tool to identify splicing regulatory elements (SREs). This method integrates multiple biological features to improve the prediction of SREs, crucial for understanding gene expression regulation.

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Using the E1A Minigene Tool to Study mRNA Splicing Changes
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Last Updated: May 21, 2026

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
08:35

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

Published on: June 24, 2021

Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Splicing regulatory elements (SREs) are critical cis-acting sequences in the splicing code.
  • Predicting SREs is challenging due to the cooperative nature of various biological signals influencing splicing patterns.

Purpose of the Study:

  • To develop a novel computational tool for discovering intronic SREs near exon junctions.
  • To integrate diverse biological features for enhanced prediction of splicing factor binding sites.

Main Methods:

  • Proposed Varying Effect Regression for Splicing Elements (VERSE) model.
  • Integrated multiple biological features to identify SREs.
  • Analyzed SREs across 16 human tissues.

Main Results:

  • Identified 1562 intronic SREs in 16 human tissues.
  • Discovered overlaps between identified SREs and known binding motifs for splicing factors (e.g., FOX-1, PTB).
  • Revealed tissue, region, and conservation preferences of SREs, indicating complex regulatory mechanisms.

Conclusions:

  • VERSE is a powerful tool for discovering SREs by integrating multiple signals.
  • The identified SREs provide insights into the intricate regulation of splice site selection.
  • VERSE can quantify the varying contributions of SREs in different biological contexts.