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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Stent thrombosis in patients with chronic kidney disease

Michael Donahue1, Carlo Briguori

  • 1Laboratory of Interventional Cardiology, Clinica Mediterranea, Naples, Italy.

Expert Review of Cardiovascular Therapy
|June 2, 2012
PubMed

Insights

Patients with chronic kidney disease face higher risks of stent thrombosis (ST) after percutaneous coronary intervention. This review examines evidence on ST with drug-eluting stents in this high-risk population.

Area of Science:

  • Cardiology
  • Nephrology
  • Biomedical Engineering

Background:

  • Chronic kidney disease (CKD) significantly increases the risk of adverse cardiac events, including death and myocardial infarction.
  • Stent thrombosis (ST), a severe complication after percutaneous coronary intervention (PCI), remains a concern despite advances in treatment.
  • Identifying high-risk patients for ST is crucial for developing effective preventive strategies.

Purpose of the Study:

  • To review the existing evidence on stent thrombosis (ST) in patients with chronic kidney disease (CKD).
  • To evaluate the safety and efficacy of drug-eluting stents (DES) in this specific patient group.
  • To highlight the need for improved risk stratification and prevention of ST in CKD patients undergoing PCI.

Main Methods:

  • Comprehensive literature search for studies on ST, PCI, drug-eluting stents, and chronic kidney disease.
  • Analysis of data regarding the incidence, risk factors, and outcomes of ST in CKD patients.
  • Synthesis of evidence to assess the role of DES in managing ST risk in this population.

Main Results:

  • CKD is a well-established predictor of adverse cardiac events post-PCI.
  • While new therapies have reduced ST rates, it remains a significant cause of morbidity and mortality.
  • Evidence regarding the specific impact of DES on ST in CKD patients requires further examination.

Conclusions:

  • Despite therapeutic advancements, stent thrombosis (ST) continues to pose a serious threat to patients with chronic kidney disease (CKD) undergoing percutaneous coronary intervention.
  • Further research is needed to refine preventive strategies and identify high-risk CKD patients susceptible to ST, particularly concerning the use of drug-eluting stents.
  • Optimizing management of CKD patients undergoing PCI is essential to mitigate the risk of life-threatening stent thrombosis.

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