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Related Concept Videos

Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...

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Related Experiment Video

Updated: May 21, 2026

Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons
09:36

Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons

Published on: May 12, 2014

Direct lineage reprogramming to neural cells.

Janghwan Kim1, Rajesh Ambasudhan, Sheng Ding

  • 1Regenerative Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, Republic of Korea.

Current Opinion in Neurobiology
|June 2, 2012
PubMed
Summary
This summary is machine-generated.

Direct reprogramming converts mature cells into other cell types, offering new avenues for regenerative medicine and disease modeling. This review focuses on reprogramming to neural cells, highlighting current progress and future challenges.

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Last Updated: May 21, 2026

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09:36

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Area of Science:

  • Cell biology
  • Neuroscience
  • Regenerative medicine

Background:

  • Recent studies demonstrate direct reprogramming, converting mature somatic cells into different cell types.
  • This process reveals significant plasticity in differentiated cells.
  • It opens doors for regenerative therapies and disease modeling.

Purpose of the Study:

  • To review the current advancements in direct lineage reprogramming towards neural cells.
  • To discuss the challenges and future potential of this technology.

Main Methods:

  • Review of existing literature on direct reprogramming techniques.
  • Analysis of studies focusing on neural cell induction from somatic cells.

Main Results:

  • Direct reprogramming is a viable method for generating diverse cell types.
  • Significant progress has been made in reprogramming to neural lineages.
  • The plasticity of somatic cells is greater than previously thought.

Conclusions:

  • Direct reprogramming holds immense promise for regenerative medicine and understanding disease.
  • Further research is needed to overcome challenges in neural reprogramming.
  • This technology offers powerful tools for both therapeutic development and basic science research.