Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neonatal hypoglycemia.

L Sann1

  • 1Service de Néonatologie, Hôpital Debrousse, Lyon, France.

Biology of the Neonate
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Supplementing neonates with lipids, particularly medium-chain triglycerides, is suggested to prevent dangerous symptomatic or recurrent neonatal hypoglycemia by supporting ketone production and gluconeogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-linear patterns of growth in very low birth weight infants.

American journal of human biology : the official journal of the Human Biology Council·2017
Same author

Bilateral hand transplantation: Supporting the patient's choice.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2016
Same author

[Ethical approach to clinical uncertainty].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2006
Same author

[Recombinant Human Erythropoietin (r-HuEPO) therapy in a newborn with hereditary spherocytosis].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2003
Same author

[Outcome of 249 premature infants, less than 29 weeks gestational age].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2001
Same author

-A new role for the pediatrician: the prevention of social violence-.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·1999
Same journal

Prevalence of two tumor necrosis factor gene polymorphisms in premature infants with early onset sepsis.

Biology of the neonate·2006
Same journal

Can cerebrospinal fluid uric acid levels differentiate intraventricular hemorrhage from traumatic tap?

Biology of the neonate·2006
Same journal

Hypoxia potentiates endotoxin-induced allopregnanolone concentrations in the newborn brain.

Biology of the neonate·2006
Same journal

Thymus involution and cerebral white matter damage in extremely low gestational age neonates.

Biology of the neonate·2006
Same journal

Primary repair of esophageal atresia in extremely low birth weight infants: a single-center experience and review of the literature.

Biology of the neonate·2006
Same journal

Systemic and pulmonary effects of vasopressors and inotropes in the neonate.

Biology of the neonate·2006
See all related articles

Area of Science:

  • Biochemistry
  • Neonatal Medicine
  • Metabolic Disorders

Background:

  • Neonatal hypoglycemia poses significant risks to brain development, especially when symptomatic or recurrent.
  • The neonatal brain actively utilizes ketone bodies as an energy source during hypoglycemia.
  • Stimulating neonatal gluconeogenesis is crucial for preventing recurrent hypoglycemia, but is limited by glucose and insulin levels.

Purpose of the Study:

  • To investigate the role of lipid administration in managing neonatal hypoglycemia.
  • To explore the mechanisms by which lipids influence gluconeogenesis and ketogenesis in neonates.
  • To propose an optimal strategy for preventing neonatal hypoglycemia.

Main Methods:

  • The study reviews existing literature on neonatal metabolism and hypoglycemia management.

Related Experiment Videos

  • It analyzes the metabolic effects of lipid administration, including impact on glucose and ketone body levels.
  • The relationship between lipid-induced gluconeogenesis and ketogenesis is examined.

    • Main Results:

    • Lipid administration was found to induce a hyperglycemic response by stimulating gluconeogenesis.
    • Lipids also promote ketogenesis, providing essential compensatory factors for hypoglycemia.
    • Ketogenesis appears to be closely linked with lipid-stimulated gluconeogenesis.

    Conclusions:

    • Lipid supplementation, especially with medium-chain triglycerides, is a promising strategy for preventing neonatal hypoglycemia.
    • This approach supports both glucose production and the provision of ketone bodies, crucial for neonatal brain energy.
    • Optimizing lipid and medium-chain triglyceride administration could be key to avoiding severe neonatal hypoglycemia.