Related Experiment Video
Updated: Jan 30, 2026
06:58
Global Identification of Co-Translational Interaction Networks by Selective Ribosome Profiling
Published on: October 7, 2021
3.0K
Identification in an anaerobic batch system: global sensitivity analysis, multi-start strategy and optimization
Andres Donoso-Bravo1, Johan Mailier, Gonzalo Ruiz-Filippi
1Automatic Control Laboratory, University of Mons, 31 Boulevard Dolez, 7000 Mons, Belgium. adonosobravo@gmail.com
Bioprocess and Biosystems Engineering
|June 2, 2012
Summary
This study introduces a reliable 3-step method for estimating parameters in anaerobic digestion (AD) models, improving accuracy and understanding of the process. Global sensitivity analysis and a multi-start strategy were key to reliable kinetic and stoichiometric parameter estimation.
Area of Science:
- Biochemical Engineering
- Environmental Science
- Mathematical Modeling
Background:
- Anaerobic digestion (AD) systems are crucial for waste management and biogas production.
- Mathematical models are widely used to simulate AD processes, but parameter estimation and validation remain challenging.
- Identifiability issues in AD models are often overlooked, hindering reliable parameter estimation.
Purpose of the Study:
- To present a robust 3-step procedure for reliable estimation of kinetic and stoichiometric parameters in a simplified AD model.
- To address the common neglect of structural and parametric identifiability in AD modeling studies.
- To validate the proposed procedure using experimental data from a lab-scale sequencing batch reactor.
Main Methods:
- A 3-step procedure combining global sensitivity analysis, multi-start strategy, and optimization criteria selection.
- Global sensitivity analysis to assess parameter interactions.
- Application of the classical least-squares cost function for parameter estimation.
Main Results:
- Successfully estimated two kinetic parameters and two stoichiometric coefficients for the simplified AD model.
- Determined the accuracy of the estimated parameters.
- Identified the classical least-squares cost function as the optimal choice for this specific case study.
Conclusions:
- The proposed 3-step procedure offers a reliable approach for parameter estimation in AD models.
- Accurate parameter estimation is crucial for effective model validation and process optimization in anaerobic digestion.
- The classical least-squares method proved effective for parameter estimation in the studied lab-scale reactor.
Related Concept Videos
01:30Introduction to Global Positioning System
507
The Global Positioning System (GPS) revolutionized positioning on Earth, providing precise location data through satellite ranging. The GPS system was developed in 1978 by the U.S. Department of Defense for military use, and it became available for civilian applications in 1983, transforming fields including navigation, fleet management, and time synchronization for telecommunications systems.GPS consists of satellites in medium Earth orbit, about 20,200 kilometers above the surface,...
507
01:26Pharmacokinetic Models: Comparison and Selection Criterion
357
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
357
01:50Global Climate Change
28.9K
Throughout its ~4.5 billion year history, the Earth has experienced periods of warming and cooling. However, the current drastic increase in global temperatures is well outside of the Earth’s cyclic norms, and evidence for human-caused global climate change is compelling. Paleoclimatology, the study of ancient climate conditions, provides ample evidence for human-caused global climate change by comparing recent conditions with those in the past.
28.9K
01:15Routh-Hurwitz Criterion I
597
Consider an electrical power grid, where stability is essential to prevent blackouts. The Routh-Hurwitz criterion is a valuable tool for assessing system stability under varying load conditions or faults. By analyzing the closed-loop transfer function, the Routh-Hurwitz criterion helps determine whether the system remains stable.
To apply the Routh-Hurwitz criterion, a Routh table is constructed. The table's rows are labeled with powers of the complex frequency variable s, starting from the...
To apply the Routh-Hurwitz criterion, a Routh table is constructed. The table's rows are labeled with powers of the complex frequency variable s, starting from the...
597
01:19Routh-Hurwitz Criterion II
1.1K
In the application of the Routh-Hurwitz criterion, two specific scenarios can arise that complicate stability analysis.
The first scenario occurs when a singular zero appears in the first column of the Routh table. This situation creates a division by zero issues. To resolve this, a small positive or negative number, denoted as epsilon (∈), is substituted for the zero. The stability analysis proceeds by assuming a sign for ∈. If ∈ is positive, any sign change in the first...
The first scenario occurs when a singular zero appears in the first column of the Routh table. This situation creates a division by zero issues. To resolve this, a small positive or negative number, denoted as epsilon (∈), is substituted for the zero. The stability analysis proceeds by assuming a sign for ∈. If ∈ is positive, any sign change in the first...
1.1K
01:16Potential-Energy Criterion for Equilibrium
938
Potential energy or potential function plays an essential role in determining the stability of a mechanical system. If a system is subjected to both gravitational and elastic forces, the potential function of the system can be expressed as the algebraic sum of gravitational and elastic potential energy. If the system is in equilibrium and is displaced by a small amount, then the work done on the system equals the negative of the change in the system's potential energy from the initial to the...
938