Related Experiment Video
Updated: May 21, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
Published on: September 27, 2017
Fire-retardant clothing-related dermatitis
Daniela C McConnell1, Thomas J Harris, Stephen B Tucker
1Department of Dermatology, University of Texas Medical School, Houston, TX 77030, USA.
Background:
Several laborers in a refinery unit undergoing a work over noted skin eruptions. Signs and symptoms included erythema, pruritus, scaling, and perifollicular inflammation on skin contacted by fire-retardant clothing (FRC).
Objective:
The purposes of this report were to show a correlation between this rash outbreak and the use of FRC, to report the investigative results as to what aspect of the FRC most likely caused the dermatitis, and to present how this outbreak was ended.
Methods:
Employees received questionnaires, were examined, and received patch testing, and pH testing of FRC was performed to evaluate the causative factors.
Results:
More than 100 workers reported a rash, and approximately a third of these individuals exhibited a unique rash. There was a trend toward Hispanic and white workers being more affected than black workers. The onset of the rash peaked from June to August. This FRC-related rash resolved with the use of manufacturer-recommended laundering procedures.
Conclusions:
The FRC-associated eruption was most likely a form of irritant contact dermatitis due to inadequate laundering procedures. The most effective preventative measure other than proper laundering was the use of underclothing to prevent contact of FRC with sweat-moistened skin.
Related Concept Videos
Drug Toxicity: Allergic Reactions
Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
PPE Use in Healthcare Settings II: Doffing
Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
