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Do stone formers have lower urinary fibrinolytic activity than controls?
B M Margetts1, D J Barker, J P Kavanagh
1MRC Environmental Epidemiology Unit, General Hospital, Southampton.
British Journal of Urology
|December 1, 1990
Summary
Urinary fibrinolytic activity did not differ significantly between stone formers and controls, questioning its role in kidney stone disease. Reduced meat intake may increase this activity, potentially explaining prior study discrepancies.
Area of Science:
- Urology
- Nephrology
- Biochemistry
Background:
- Previous research suggested lowered urinary fibrinolytic activity as a potential risk factor for renal stone disease.
- An earlier independent observation indicated a significant difference in this activity between stone formers and controls.
Purpose of the Study:
- To compare urinary fibrinolytic activity in individuals with and without kidney stones.
- To investigate the potential association between dietary meat intake and urinary fibrinolytic activity in stone formers.
Main Methods:
- Comparative analysis of urinary fibrinolytic activity.
- Data collection on dietary habits, specifically meat consumption.
- Statistical comparison between a cohort of 31 stone formers and 50 controls.
Main Results:
- No significant difference in urinary fibrinolytic activity was found between stone formers and controls.
- This finding failed to confirm the earlier independent observation.
- Dietary data suggested a possible association between reduced meat intake and increased urinary fibrinolytic activity in stone formers.
Conclusions:
- The significance of lowered urinary fibrinolytic activity as a risk factor for renal stone disease requires further investigation due to conflicting results.
- Methodological and design differences between studies may explain discrepancies.
- Dietary modifications, such as reduced meat intake, could influence urinary fibrinolytic activity and warrant further research in the context of kidney stone prevention.