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Related Experiment Video

Updated: May 21, 2026

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Physical urticaria.

Marina Abajian¹, Agnieszka Młynek, Marcus Maurer

¹Department of Dermatology and Allergy, Allergie-Centrum-Charité/ECARF, Charité-Universitätsmedizin Berlin, Germany. marina.abajian@charite.de

Current Allergy and Asthma Reports

|June 2, 2012

Summary

Physical urticarias are chronic hives triggered by physical stimuli like cold or pressure, affecting young adults. Effective management involves identifying triggers and symptomatic treatment for wheal and flare responses.

Area of Science:

Dermatology
Immunology

Background:

Physical urticarias are a diverse group of chronic hives.
They are triggered by specific physical stimuli such as cold, heat, pressure, vibration, or sunlight.
These conditions account for up to 25% of chronic urticaria cases, predominantly affecting young adults.

Purpose of the Study:

To summarize the clinical features of physical urticarias.
To outline the diagnostic workup for physical urticarias.
To review the available therapy options for physical urticarias.

Main Methods:

Review of clinical features.
Summary of diagnostic approaches.
Compilation of therapeutic strategies.

Main Results:

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Symptoms like wheal and flare responses or angioedema are typically localized to stimulated skin areas.
Generalized urticaria with extracutaneous manifestations can occur.
Some patients may experience more than one type of physical urticaria.

Conclusions:

Physical urticarias result from mast cell activation, though underlying mechanisms are not fully understood.
Trigger avoidance and symptomatic treatment are central therapeutic concepts.
Identifying the specific physical trigger and individual thresholds is crucial for effective management.