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Updated: May 21, 2026

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants
Published on: December 21, 2021
Maternal genetic effect in DNA analysis: egg on your traits.
1Pediatrics, Obstetrics and Gynecology, Texas Tech University Health Science Centers, Dallas, Texas 75209, USA. golder.wilson@ttuhsc.edu
Maternal genetic effects can explain why identical genetic changes cause disease in children but not mothers. This highlights the need to consider maternal inheritance in human DNA analysis for accurate diagnosis.
Area of Science:
- Genetics
- Developmental Biology
- Human Molecular Variation
Background:
- Penetrance, the likelihood a gene variant expresses a trait, presents challenges in human molecular variation analysis.
- Maternal genetic effects are proposed mechanisms for mother-offspring discordance in genetic findings.
- Identical genetic changes in mothers and children necessitate careful evaluation beyond benign variation.
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