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Cysteine cathepsin S processes leptin, inactivating its biological activity

Marcela Oliveira1, Diego M Assis, Thaysa Paschoalin

  • 1Departamento de Biofísica, Universidade Federal de São Paulo, Rua Pedro de Toledo 669, São Paulo, São Paulo 04039-032, Brazil.

The Journal of Endocrinology
|June 2, 2012
PubMed
Summary

Cysteine cathepsins, particularly cathepsin S, degrade leptin in white adipose tissue. This process inactivates leptin’s functions, suggesting cathepsins regulate leptin activity.

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