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[Animal models of human glioma: the progress of application and investigation]

Hui-Fang Zhu1, Yuan-Xu Zhang, Xu-Dong Zhao

  • 1Chinese Academy of Science, Kunming, China.

Dong Wu Xue Yan Jiu = Zoological Research
|June 2, 2012
PubMed

Insights

Glioma, a common brain tumor, presents therapeutic challenges. This review covers various animal models crucial for advancing glioma research and preclinical studies.

Area of Science:

  • Neuro-oncology
  • Cancer Biology
  • Translational Medicine

Context:

  • Glioma represents 50% of central nervous system tumors.
  • Glioblastoma multiforme (GBM) is a highly aggressive and lethal brain tumor.
  • Therapeutic challenges necessitate effective preclinical models.

Purpose:

  • To review established animal models for human glioma.
  • To highlight advancements in molecular biology, genetics, and transgenic technologies for model development.
  • To provide a resource for selecting appropriate models for glioma research.

Summary:

  • This paper reviews various animal models developed for studying human glioma.
  • These models leverage advancements in molecular biology, genetics, and transgenic technologies.
  • The review focuses on models suitable for preclinical studies of glioma and glioblastoma multiforme.

Impact:

  • Facilitates the selection of appropriate animal models for glioma research.
  • Aids in the development of novel therapeutic strategies for brain tumors.
  • Supports preclinical testing and validation of new glioma treatments.

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