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Updated: Aug 8, 2026
03:55
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
Chromosomal changes in thyroid tumors. Relation with DNA content, karyotypic features, and clinical data
J R Teyssier1, F Liautaud-Roger, D Ferre
1Laboratories of Histology-Embryology-Cytogenetics (INSERM U314), Reims, France.
Cancer Genetics and Cytogenetics
|December 1, 1990
Summary
Cytogenetic analysis of thyroid tumors reveals chromosomal abnormalities in nearly half of carcinomas and a third of adenomas. Alterations in chromosome 7 were linked to aggressive cancer behavior and poor patient outcomes.
Area of Science:
- Oncology
- Genetics
- Pathology
Background:
- Thyroid tumors encompass a spectrum of neoplasms, including adenomas and carcinomas, with varying degrees of aggressiveness.
- Cytogenetic analysis provides insights into the molecular underpinnings of tumor development and progression.
Purpose of the Study:
- To investigate the role of chromosomal abnormalities in thyroid tumors.
- To correlate cytogenetic findings with tumor type, behavior, and patient outcomes.
Main Methods:
- A monolayer short-term culture technique was employed for cytogenetic analysis of 63 thyroid tumors.
- Clonal chromosomal changes were identified and quantified.
- Modal DNA index measurements were correlated with chromosomal findings.
- Quantitative morphometric analysis of nuclear features was performed.
Main Results:
- Clonal chromosomal changes were detected in 47% of thyroid carcinomas and 31% of adenomas.
- Chromosome 7 alterations were present in 40% of cytogenetically abnormal tumors.
- Modal DNA index was consistent with chromosomal mode in 88% of cases.
- Morphometric analysis differentiated diploid adenomas with different translocation statuses, suggesting distinct biological properties.
- Aggressive carcinomas exhibited clonal chromosomal changes in 78% of cases, compared to 28% in those without risk factors.
- Two patients with early mortality showed chromosome 7 abnormalities.
Conclusions:
- Cytogenetic alterations are common in thyroid tumors and may serve as biomarkers for tumor behavior.
- Specific chromosomal changes, particularly involving chromosome 7, are associated with aggressive thyroid carcinomas and potentially poorer prognosis.
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