Successful salvage therapy of Fusarium endophthalmitis secondary to keratitis: an interventional case series
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Updated: May 21, 2026
Iris Fixation via External Pentagram Suturing
Published on: May 5, 2022
Grant M Comer1, Maxwell S Stem, Stephen J Saxe
1University of Michigan, Department of Ophthalmology and Visual Sciences, Ann Arbor, MI, USA.
Purpose:
To describe a combination of treatment modalities used for the successful eradication of Fusarium endophthalmitis.
Design:
Interventional case series.
Participants:
Three consecutive patients with keratitis-associated Fusarium endophthalmitis.
Methods:
After failure of traditional management options, a combination of intravitreal and long-term, high-dose systemic voriconazole, topical antifungal medications, and surgical intervention, with penetrating keratoplasty, lensectomy, and endoscopic-guided pars plana vitrectomy, was administered to each patient.
Results:
All three cases achieved full resolution of the infection, with a final Snellen visual acuity score of 20/50 to 20/70.
Conclusions:
An aggressive combination of therapeutic modalities, including the removal of subiris abscesses, might be needed for the successful resolution of Fusarium endophthalmitis.