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Updated: May 21, 2026

Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions
08:59

Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions

Published on: April 18, 2015

Calcium-dependent signaling in Dupuytren's disease

Josef G Hadeed, Jennifer E Bond, M Angelica Selim

    Hand (New York, N.Y.)
    |June 2, 2012
    PubMed
    Summary

    Fluphenazine inhibits Dupuytren's fibroblast contractility and migration by targeting myosin light chain kinase (MLCK). However, inconsistent MLCK expression suggests this pathway may not be a primary treatment target for Dupuytren's disease.

    Keywords:
    Calcium-dependent signaling

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