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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
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Related Experiment Video

Updated: May 21, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Mast cell: an emerging partner in immune interaction.

Giorgia Gri1, Barbara Frossi, Federica D'Inca

  • 1Immunology Laboratory, Department of Medical and Biological Science, University of Udine Udine, Italy.

Frontiers in Immunology
|June 2, 2012
PubMed
Summary

Mast cells (MCs) are crucial immune cells with diverse roles. Their surface molecules regulate immune responses, influencing inflammation, tolerance, and disease.

Keywords:
adaptive immunitycell–cell interactioninnate immunitymast cell

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Last Updated: May 21, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
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11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Mast cells (MCs) are key immune effector cells involved in host defense, immune regulation, allergy, inflammation, and autoimmune diseases.
  • MCs secrete diverse bioactive products and their functions are modulated by cell-cell and cell-extracellular matrix interactions via membrane molecules.

Purpose of the Study:

  • To review and discuss the central role of mast cell membrane-expressed molecules in regulating MC priming and activation.
  • To explore how these molecules modulate innate and adaptive immune responses, including peripheral tolerance and tumor surveillance/escape.

Main Methods:

  • Review of existing scientific literature and evidence.
  • Discussion of the roles and functions of newly discovered molecules in MC cross-talk.

Main Results:

  • MC membrane molecules are central regulators of MC activation and effector functions.
  • Complex expression patterns of MC surface molecules indicate distinct functional states and cell-cell interaction capabilities.
  • These molecules mediate communication between MCs and both immune and non-immune cells.

Conclusions:

  • Mast cell surface molecules are critical for modulating immune responses, impacting health and disease.
  • Understanding MC membrane molecule interactions offers insights into immune regulation, tolerance, and cancer immunity.