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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
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Published on: August 21, 2013

PPARs: Interference with Warburg' Effect and Clinical Anticancer Trials.

Joseph Vamecq1, Jean-Marie Colet, Jean Jacques Vanden Eynde

  • 1Inserm, HMNO, CBP, CHRU Lille, 59037 Lille, France.

PPAR Research
|June 2, 2012
PubMed
Summary
This summary is machine-generated.

Cancer cells exhibit altered metabolism, including aerobic glycolysis driven by hypoxia-induced factor (HIF-1). PPAR ligands show promise in targeting tumoral metabolism for cancer treatment, potentially combined with other agents.

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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Area of Science:

  • Oncology
  • Cancer Metabolism
  • Molecular Signaling

Background:

  • The Warburg effect (aerobic glycolysis) and general cancer cell metabolic phenotypes are reviewed.
  • Hypoxia-induced factor (HIF-1) plays a central role in aerobic glycolysis expression.
  • Cancer metabolism is influenced by signaling pathways like ras, myc, p53, and Akt.

Purpose of the Study:

  • To provide an integrated view of tumoral metabolism.
  • To explore emerging cancer treatment strategies.
  • To examine the role of PPAR ligands in cancer therapy.

Main Methods:

  • Review of metabolic and cell signaling pathways in cancer.
  • Analysis of signaling aberrances and their therapeutic implications.
  • Examination of PPAR ligand mechanisms and clinical trial data.

Main Results:

  • Cancer metabolic phenotype involves aerobic glycolysis and altered signaling routes.
  • Aberrant signaling in cancer cells presents therapeutic intervention opportunities.
  • PPAR ligands demonstrate potential to interfere with tumoral metabolism and exhibit anticancer activity.

Conclusions:

  • Emerging cancer treatment strategies target tumoral metabolism.
  • PPAR ligands offer a direct mechanism to impact cancer metabolism.
  • Combining PPAR ligands with other anticancer agents may be crucial for effective treatment.