Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 21, 2026

Thermal Ablation for the Treatment of Abdominal Tumors

Thermal Ablation for the Treatment of Abdominal Tumors

Published on: March 7, 2011

Hyperthermic intraoperative thoracoabdominal chemotherapy.

Paul H Sugarbaker¹, David Chang, O Anthony Stuart

¹Washington Hospital Center, Washington Cancer Institute, 106 Irving Street, NW, Suite 3900, Washington, DC 20010, USA.

Gastroenterology Research and Practice

|June 2, 2012

Summary

Hyperthermic thoracoabdominal chemotherapy (HITAC) after diaphragm resection offers acceptable survival for pseudomyxoma peritonei and mesothelioma patients, with low intrathoracic recurrence despite high morbidity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Outcomes of stereotactic ablative body radiotherapy for treatment of oligometastatic gynecological cancers: a narrative review.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2026

Same author

Partially Ablative Body Radiation Therapy Versus Standard Palliative Radiation Therapy for Locally Advanced Bulky Unresectable Sarcomas.

Advances in radiation oncology·2026

Same author

Engaging communities in recovery: Evaluation of a patient and family advisory committee supporting implementation of the Road to Recovery model of substance use care in British Columbia.

Drug and alcohol dependence reports·2026

Same author

Patients with an acetabular fracture treated with acute total hip arthroplasty and additional fixation: a cohort study with functional and radiological follow-ups.

Acta orthopaedica·2026

Same author

Case study of resecabtagene autoleucel in a subject with diffuse cutaneous systemic sclerosis treated in the RESET-SSc trial.

Molecular therapy. Advances·2026

Same author

Corrigendum to "Surgery or no surgery for pediatric uncomplicated appendicitis? A systematic review and meta-analysis to inform management" [Surgery 188 (2025) 109728].

Surgery·2026

Area of Science:

Surgical Oncology
Medical Oncology
Pharmacology

Background:

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) treats pseudomyxoma peritonei (PMP) and diffuse malignant peritoneal mesothelioma (DMPM).
Diaphragm infiltration necessitates resection, increasing the risk of cancer spread from the abdomen to the chest.

Purpose of the Study:

To evaluate the safety and efficacy of hyperthermic thoracoabdominal chemotherapy (HITAC) in patients undergoing diaphragm resection.
To compare HITAC with hyperthermic intraperitoneal chemotherapy (HIPEC) and hyperthermic intrathoracic chemotherapy (HITOC) regarding drug absorption, morbidity, mortality, and recurrence.

Main Methods:

A prospective database identified 30 patients who underwent diaphragm resection and HITAC as part of cytoreductive surgery.

More Related Videos

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

Related Experiment Videos

Last Updated: May 21, 2026

Thermal Ablation for the Treatment of Abdominal Tumors

Thermal Ablation for the Treatment of Abdominal Tumors

Published on: March 7, 2011

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

Pharmacokinetic data (area under the curve) for mitomycin C and doxorubicin were analyzed.

Chemotherapy absorption and clinical outcomes (morbidity, mortality, survival, intrathoracic recurrence) were compared to control groups receiving HIPEC or HITOC.

Main Results:

HITAC demonstrated significant intracavitary drug concentrations (AUC ratios: 27±10 for mitomycin C, 75±26 for doxorubicin).
Chemotherapy absorption was highest with HIPEC, followed by HITAC, and lowest with HITOC.
The incidence of grade 3-4 adverse events was 43%, with no mortality. Intrathoracic recurrence was low, and dose adjustments were not needed.

Conclusions:

HITAC is a viable treatment option for PMP and DMPM patients with diaphragm involvement, offering acceptable survival and low intrathoracic recurrence.
While HITAC involves significant morbidity, it achieves adequate drug delivery to the thoracic cavity without requiring chemotherapy dose adjustments.