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Chemotherapy in penile cancer
Oliver W Hakenberg1, Chris Protzel
1Urologische Universitätsklinik Ernst-Heydemann-Strasse 6 D-18059 Rostock Germany.
Therapeutic Advances in Urology
|June 2, 2012
Summary
Penile cancer is aggressive and hard to cure once it spreads. Chemotherapy, especially with taxanes and cisplatinum, combined with surgery, offers the best treatment for lymphatic metastases.
Area of Science:
- Oncology
- Urologic Oncology
Background:
- Penile cancer is an aggressive malignancy with poor prognosis after systemic progression.
- Squamous cell carcinoma of the penis presents treatment challenges, particularly with lymphatic metastases.
Purpose of the Study:
- To review current chemotherapy approaches for penile cancer.
- To highlight the need for advanced multimodal care strategies.
Main Methods:
- Review of recent advances in chemotherapy regimens for penile cancer.
- Emphasis on the role of taxanes and cisplatinum.
Main Results:
- Chemotherapy shows efficacy, but aggressive surgical treatment is crucial for lymphatic metastases.
- Limited clinical data exists due to the rarity of penile carcinoma.
Conclusions:
- Current chemotherapy regimens are evolving, incorporating less toxic options like taxanes.
- Cisplatinum remains a cornerstone of treatment.
- Multi-institutional studies are essential to improve multimodal care for penile cancer patients.
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