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Related Experiment Video

Updated: May 21, 2026

Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly
10:17

Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly

Published on: November 4, 2021

Uniform yeast cell assembly via microfluidics.

Ya-Wen Chang, Peng He, Samantha M Marquez

    Biomicrofluidics
    |June 2, 2012
    PubMed
    Summary
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    Researchers created yeastosomes using microfluidic technology and self-assembling yeast cells. This method offers precise control for building complex biological structures from living cells.

    Area of Science:

    • Biomaterials Science
    • Microfluidics
    • Synthetic Biology

    Background:

    • Cellular self-assembly is a key process in biological systems.
    • Microfluidic devices offer precise control over fluid dynamics and particle manipulation.
    • Fabricating complex biological structures from living cells presents significant challenges.

    Purpose of the Study:

    • To develop a microfluidic approach for fabricating yeastosomes (yeast-celloidosomes).
    • To investigate the self-assembly of yeast cells onto liquid interfaces for bio-structure creation.
    • To establish a versatile platform for designing synthetic hierarchical biological structures.

    Main Methods:

    • Utilized droplet- and bubble-forming microfluidic devices for controlled fluidic flows.
    • Employed self-assembly of yeast cells onto liquid-solid or liquid-gas interfaces.

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    High Throughput Yeast Strain Phenotyping with Droplet-Based RNA Sequencing
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    Published on: May 21, 2020

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    Last Updated: May 21, 2026

    Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly
    10:17

    Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly

    Published on: November 4, 2021

    A Microfluidic Device for Studying Multiple Distinct Strains
    08:15

    A Microfluidic Device for Studying Multiple Distinct Strains

    Published on: November 9, 2012

    High Throughput Yeast Strain Phenotyping with Droplet-Based RNA Sequencing
    07:55

    High Throughput Yeast Strain Phenotyping with Droplet-Based RNA Sequencing

    Published on: May 21, 2020

  • Applied Layer-by-Layer (LbL) polyelectrolyte deposition to tune surface charges and electrostatic attractions.

    • Main Results:

    • Achieved production of monodispersed, size-selected templates using microfluidics.
    • Demonstrated successful organization and assembly of living yeast cells.
    • Produced high-quality, monolayer-shelled yeastosome structures under optimized conditions.

    Conclusions:

    • Microfluidic fabrication combined with cell self-assembly provides a versatile platform.
    • This approach enables the design of synthetic hierarchical bio-structures.
    • The method allows precise control over the assembly of living cells into functional structures.