Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Toxidromes: Clinical Features

Toxidromes: Clinical Features

Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...

Drug Toxicity: Overview

Drug Toxicity: Overview

Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...

Prevention of Further Absorption of Poison

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...

Antidotes

Antidotes

Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Seizure as a Rare Initial Manifestation of Empty Sella Turcica Associated With Idiopathic Intracranial Hypertension: A Case Report.

Case reports in medicine·2026

Same author

An unusual case of invasive rhino-cerebral aspergillosis in a pediatric patient: A case report with diagnostic approach and imaging review.

Radiology case reports·2026

Same author

Performance of the pediatric index of mortality (PIM-3) in a Moroccan PICU: challenges in resource-limited settings.

European journal of pediatrics·2025

Same author

The stroke that unveiled a silent threat: rupture and thrombosis of hydatid cyst in the left ventricle- a case report.

Journal of cardiothoracic surgery·2025

Same author

Systemic Lupus Erythematosus-Associated Thrombotic Thrombocytopenic Purpura: A Case Report.

Cureus·2025

Same author

Timing of kidney replacement therapy in critically ill patients: A call to shift the paradigm in the era of artificial intelligence.

Science progress·2025

Search research articles

Related Experiment Video

Updated: May 21, 2026

Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry

Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry

Published on: October 2, 2016

Atropa belladonna intoxication: a case report.

Mohamed Adnane Berdai¹, Smael Labib, Khadija Chetouani

¹Intensive Care Unit, Mother and Child Hospital, University Hospital Hassan II, Fes, Morrocco.

The Pan African Medical Journal

|June 2, 2012

Summary

This summary is machine-generated.

Deadly nightshade (Atropa belladonna) poisoning is a severe condition, especially in children. Prompt symptomatic treatment, including activated charcoal and potentially physostigmine, is crucial for managing anti-cholinergic toxidrome.

Keywords:

Intoxication anticholinergic toxidrome atropa belladonna atropine child

More Related Videos

A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

Published on: November 14, 2014

Related Experiment Videos

Last Updated: May 21, 2026

Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry

Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry

Published on: October 2, 2016

A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

Published on: November 14, 2014

Area of Science:

Toxicology
Pharmacology

Background:

Atropa belladonna, or deadly nightshade, contains toxic alkaloids like atropine, hyoscyamine, and scopolamine.
Accidental poisoning is a significant risk, particularly in children due to berry misidentification.

Observation:

A case report details an 11-year-old girl presenting with central anti-cholinergic syndrome after ingesting Atropa belladonna.
The plant was administered therapeutically for jaundice, highlighting a dangerous misconception.

Findings:

The patient exhibited symptoms consistent with severe anti-cholinergic toxidrome.
Diagnosis involved considering other atropine-containing plants or drugs.

Implications:

This case underscores the critical need for awareness regarding deadly nightshade toxicity and its potential for severe poisoning.
Effective management relies on symptomatic treatment, gastrointestinal decontamination, and in severe instances, physostigmine administration.