A primary synovial sarcoma of lung
1Department of Pulmonary Medicine, Midnapore Medical College, Midnapore, Paschim Midnapore, India.
North American Journal of Medical Sciences
|June 2, 2012
Summary
Primary pulmonary synovial sarcoma is an extremely rare lung cancer. Diagnosis requires excluding other sarcomas and involves histopathology and immunohistochemistry for confirmation.
Area of Science:
- Oncology
- Pathology
Background:
- Primary pulmonary synovial sarcoma is a rare malignant neoplasm of the lung.
- Diagnosis is challenging, requiring exclusion of primary lung malignancies and metastatic sarcoma.
Observation:
- A case of a 55-year-old man with left-sided chest pain and shortness of breath is presented.
- Imaging revealed a large heterogeneous mass in the left hemithorax with pleural effusion.
- CT-guided biopsy showed spindle cell sarcoma.
Findings:
- Immunohistochemistry revealed tumor cells expressing EMA, CD99, bcl-2, and Calponin, with cytokeratin negativity.
- Final diagnosis confirmed primary pulmonary synovial sarcoma.
Implications:
- This case highlights the rarity of primary pulmonary synovial sarcoma.
- Accurate diagnosis relies on histopathology, immunohistochemistry, and potentially cytogenetics.
- Further research into this rare lung malignancy is warranted.
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