Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plasma high density lipoprotein cholesterol in thyroid disease.

D Agdeppa, C Macaron, T Mallik

    The Journal of Clinical Endocrinology and Metabolism
    |November 1, 1979
    PubMed
    Summary

    Thyroid dysfunction impacts cholesterol levels. Both hyperthyroidism and hypothyroidism are associated with reduced high density lipoprotein cholesterol (HDL-C) in women, with levels improving after treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Recurrence of Disease Following Liver Transplantation: Nonalcoholic Steatohepatitis vs Hepatitis C Virus Infection.

    International journal of organ transplantation medicine·2014
    Same author

    Rate of tumor growth predicts recurrence of hepatocellular carcinoma after liver transplantation in patients beyond Milan or UCSF criteria.

    Transplantation proceedings·2011
    Same author

    Total tumor volume predicts recurrence of hepatocellular carcinoma after liver transplantation in patients beyond Milan or UCSF criteria.

    Transplantation proceedings·2010
    Same author

    Urinary cotinine in narguila or chicha tobacco smokers.

    Le Journal medical libanais. The Lebanese medical journal·1997
    Same author

    An epidemic of hyperthyroidism following salt iodination in Lebanon.

    Le Journal medical libanais. The Lebanese medical journal·1996
    Same author

    Histidyl-proline diketopiperazine cyclo (His-Pro): measurement by radioimmunoassay in human blood in normal subjects and in patients with hyper- and hypothyroidism.

    Biochemical and biophysical research communications·1982

    Area of Science:

    • Endocrinology
    • Cardiovascular Health
    • Lipid Metabolism

    Background:

    • Thyroid hormones play a crucial role in regulating various metabolic processes.
    • Alterations in thyroid status, such as hyperthyroidism and hypothyroidism, may influence lipid profiles.
    • High density lipoprotein cholesterol (HDL-C) is a key indicator of cardiovascular health.

    Purpose of the Study:

    • To investigate the relationship between thyroid dysfunction (hyperthyroidism and hypothyroidism) and plasma high density lipoprotein cholesterol (HDL-C) levels in women.
    • To assess the impact of restoring euthyroid state on HDL-C levels in hyperthyroid patients.
    • To evaluate the effect of L-T4 replacement therapy on HDL-C in hypothyroid patients.

    Main Methods:

    • Cross-sectional comparison of HDL-C levels in hyperthyroid and hypothyroid women versus euthyroid controls.
    • Longitudinal assessment of HDL-C levels before and after treatment in hyperthyroid and hypothyroid patients.
    • Intervention study administering L-T4 to normal male volunteers.

    Main Results:

    • Plasma HDL-C levels were significantly reduced in hyperthyroid women compared to euthyroid controls (P < 0.001).
    • Following treatment to restore the euthyroid state, HDL-C levels increased significantly in previously hyperthyroid patients (P < 0.05).
    • Hypothyroid women also exhibited diminished HDL-C levels compared to euthyroid controls (P < 0.05), with a non-significant increase after L-T4 therapy.

    Conclusions:

    • Thyroid dysfunction, both hyperthyroidism and hypothyroidism, is associated with lower HDL-C levels in women.
    • Restoration of euthyroid state improves HDL-C levels in hyperthyroid individuals.
    • Further research may be needed to fully elucidate the impact of thyroid hormone replacement on HDL-C in hypothyroidism.

    Related Experiment Videos