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Updated: May 21, 2026
05:10
Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Individualized weight management: what can be learned from nutrigenomics and nutrigenetics?
Iwona Rudkowska1, Louis Pérusse
1Institute of Nutraceuticals and Functional Foods (INAF), Laval University, Quebec, Canada.
Summary
Obesity results from a complex interplay between environmental factors and individual genetic predispositions. Understanding gene-nutrient interactions is key for effective weight management strategies and personalized nutrition.
Area of Science:
- Nutritional Science
- Genetics
- Obesity Research
Background:
- Rising obesity prevalence suggests environmental factors (obesogenic environment) dominate, but individual susceptibility varies.
- Genetic factors interact with environmental influences, predisposing some individuals to obesity.
- Gene-environment interactions impact obesity susceptibility and weight management outcomes.
Purpose of the Study:
- To review the role of gene-nutrient interactions in weight management.
- To explore transcriptomics in nutrition studies concerning caloric restriction and macronutrients.
- To examine how obesity gene polymorphisms affect responses to weight-loss programs.
Main Methods:
- Review of transcriptomics applications in human nutrition intervention studies.
- Analysis of molecular impacts of caloric restriction and macronutrient composition.
- Examination of obesity candidate gene polymorphisms and their effects on weight-related phenotypes in response to dietary interventions.
Main Results:
- Transcriptomics provides insights into molecular responses to dietary interventions like caloric restriction.
- Specific gene polymorphisms influence individual responses to weight-loss programs and nutritional strategies.
- Gene-nutrient interactions are critical in determining the success of weight management.
Conclusions:
- Gene-nutrient interactions are fundamental to understanding and managing obesity.
- Personalized nutrition strategies considering genetic profiles may enhance weight management efficacy.
- Further research into gene-environment and gene-nutrient interactions is crucial for public health.
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