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Updated: May 21, 2026

Intracranial Pharmacotherapy and Pain Assays in Rodents
Published on: April 9, 2019
Caffeine in the treatment of pain
Cristiane Tavares1, Rioko Kimiko Sakata
1Department of Anesthesiology, Pain and Intensive Care, Universidade Federal de São Paulo, Brazil.
Background And Objectives:
Caffeine is a widely used substance with effects on several systems, presenting characteristic of pharmacokinetic and pharmacodynamic which cause interactions with several drugs. This study's objective is to review the effects caused by caffeine.
Content:
This review assesses the caffeine pharmacology, its action mechanisms, indications, contraindications, doses, interactions and adverse effects.
Conclusions:
There are insufficient double-blind randomized controlled studies that assess the analgesic effect of caffeine on several painful syndromes. Patients presenting chronic pain need caution when it comes to tolerance development, abstinence and drug interaction from chronic caffeine use.
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