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A recombination map of the human X-chromosome
R G Del Mastro1, P A Farndon, M W Kilpatrick
1Department of Clinical Genetics, Birmingham Maternity Hospital, University of Birmingham, UK.
Human Genetics
|December 1, 1990
Abstract:
A family with 11 normal boys has been typed with DNA probes spanning the whole of the X-chromosome to observe directly the recombination events in 11 meioses from one female. This has (a) identified apparent recombination hot-spots on the X-chromosome; (b) shown the positions and numbers of cross-overs that have occurred in the p and q arms; (c) not shown any cross-overs in the centromeric region and (d) enabled the calculation of the genetic length of the X-chromosome.