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Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

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Updated: May 21, 2026

Multimodality Diagnosis of Mesenteric Ischemia
05:07

Multimodality Diagnosis of Mesenteric Ischemia

Published on: July 21, 2023

[Mesenteric panniculitis].

G Guettrot-Imbert1, L Boyer, J-C Piette

  • 1Service de médecine interne, CHU de Gabriel-Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand cedex 1, France. gguettrot-imbert@chu-clermontferrand.fr

La Revue De Medecine Interne
|June 5, 2012
PubMed
Summary
This summary is machine-generated.

Mesenteric panniculitis is an inflammatory condition of mesenteric fat, often diagnosed via CT scan. Histology is crucial for definitive diagnosis and differentiating it from other mesenteric masses.

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Area of Science:

  • Gastroenterology
  • Pathology
  • Radiology

Context:

  • Mesenteric panniculitis is a nonspecific inflammatory condition affecting mesenteric fat.
  • It presents with diverse clinical and imaging findings, often leading to diagnostic challenges.
  • The term is frequently misused, causing confusion regarding its etiology.

Purpose:

  • To clarify the definition, clinical presentation, diagnostic methods, and histopathological features of mesenteric panniculitis.
  • To differentiate mesenteric panniculitis from other mesenteric pathologies.
  • To discuss associated conditions, complications, and treatment strategies.

Summary:

  • Mesenteric panniculitis involves inflammation of mesenteric fat, with pain as a primary symptom in symptomatic cases.
  • CT scans suggest the diagnosis by showing increased mesenteric fat density, but histological examination is definitive.
  • Histological stages include lipodystrophy, mesenteric panniculitis, and sclerosing mesenteritis, with differential diagnoses including lymphomas and sarcomas.

Impact:

  • Improved understanding of mesenteric panniculitis pathophysiology can enhance patient management.
  • Accurate diagnosis through histology is vital for appropriate treatment and ruling out malignancies.
  • Further research into adipose tissue immunoregulatory functions may lead to novel therapeutic approaches.