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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

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Related Experiment Video

Updated: May 21, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

miRNA in systemic lupus erythematosus.

Gil Amarilyo1, Antonio La Cava

  • 1Department of Medicine at University of California Los Angeles, CA 90095-1670, USA. gamarilyo@mednet.ucla.edu

Clinical Immunology (Orlando, Fla.)
|June 5, 2012
PubMed
Summary

MicroRNAs (miRNAs) are small RNAs regulating gene expression. This review explores their role in systemic lupus erythematosus (SLE) pathogenesis, highlighting their function in this autoimmune disease.

Area of Science:

  • Molecular Biology
  • Immunology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small, noncoding RNA molecules that regulate gene expression post-transcriptionally.
  • They are implicated in various physiological processes and the pathogenesis of diseases, including cancer, infections, and autoimmune disorders.
  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by autoantibodies and inflammation.

Purpose of the Study:

  • To review the current literature on the role of miRNAs in the pathogenesis of systemic lupus erythematosus (SLE).
  • To elucidate the mechanisms by which miRNAs contribute to the development and progression of SLE.
  • To provide an overview of miRNAs as potential diagnostic or therapeutic targets in SLE.

Main Methods:

  • Literature review of studies investigating miRNA expression and function in SLE.

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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Related Experiment Videos

Last Updated: May 21, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

  • Analysis of mechanisms of miRNA-mediated gene regulation relevant to SLE pathogenesis.
  • Synthesis of findings from preclinical and clinical studies.

    • Main Results:

    • Specific miRNAs have been identified as dysregulated in SLE patients.
    • These miRNAs target key genes involved in immune cell function, inflammation, and apoptosis, pathways central to SLE.
    • miRNAs influence B cell activation, T cell differentiation, and cytokine production in the context of SLE.

    Conclusions:

    • MicroRNAs play a significant role in the pathogenesis of systemic lupus erythematosus.
    • Understanding miRNA dysregulation offers insights into SLE mechanisms.
    • miRNAs represent promising biomarkers and therapeutic targets for SLE management.