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Combining Analysis of DNA in a Crude Virion Extraction with the Analysis of RNA from Infected Leaves to Discover New Virus Genomes
Published on: July 27, 2018
Dobrava-Belgrade virus: phylogeny, epidemiology, disease
1National Reference Laboratory for Arboviruses, A' Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki 54006, Greece. annap@med.auth.gr
Antiviral Research
|June 5, 2012
Summary
Dobrava-Belgrade virus (DOBV), a European hantavirus, causes severe hemorrhagic fever with renal syndrome. This review updates knowledge on DOBV
Area of Science:
- Virology
- Epidemiology
- Infectious Diseases
Background:
- Dobrava-Belgrade virus (DOBV) is a significant European hantavirus causing hemorrhagic fever with renal syndrome (HFRS).
- DOBV exhibits a high case fatality rate (up to 12%) and has expanded its geographic range with novel genetic variants.
- Rodent hosts include Apodemus flavicollis, Apodemus agrarius, and Apodemus ponticus, complicating taxonomic and evolutionary understanding.
Purpose of the Study:
- To provide an updated review of DOBV phylogeny and epidemiology in rodents and humans.
- To detail clinical characteristics, diagnosis, treatment, and prevention strategies for DOBV infection.
- To discuss current advancements in antiviral and vaccine development against DOBV.
Main Methods:
- Literature review of existing studies on DOBV.
- Analysis of epidemiological data on rodent and human infections.
- Synthesis of clinical, diagnostic, and therapeutic information.
Main Results:
- DOBV shows complex evolution and genetic diversity, with ongoing taxonomic challenges.
- Epidemiological data reveal expanding endemic foci and multiple Apodemus host species.
- Clinical presentations, diagnostic methods, and treatment options are continually evolving.
Conclusions:
- Further research is needed to fully understand DOBV's complex evolution and genetic diversity.
- Integrated approaches to surveillance, diagnosis, and treatment are crucial for managing DOBV.
- Development of effective antiviral therapies and vaccines remains a priority.
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