Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 21, 2026

Mechanical Mapping of Spheroids Using Brillouin Spectroscopy

Mechanical Mapping of Spheroids Using Brillouin Spectroscopy

Published on: December 12, 2025

Focused cylindrical vector beam assisted microscopic pSPR biosensor with an ultra wide dynamic range.

Rong Wang¹, Chonglei Zhang, Yong Yang

¹Institute of Modern Optics, Key Laboratory of Optoelectronic Information Science & Technology, Ministry of Education of China, Nankai University, Tianjin, China, 300071.

|June 5, 2012

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cascaded hollow FP cavities on fiber end-face for ultrasonic and photoacoustic detection.

Optics express·2025

Same author

Glacial lake outburst floods threaten China-Nepal connectivity: Synergistic study of remote sensing, GIS and hydrodynamic modeling with regional implications.

The Science of the total environment·2024

Same author

Surpassing the resolution limitation of structured illumination microscopy by an untrained neural network.

Biomedical optics express·2023

Same author

Correction to: Ultrasonic signal detection based on Fabry-Perot cavity sensor.

Visual computing for industry, biomedicine, and art·2021

Same author

A Phase-Shifted Surface Plasmon Resonance Sensor for Simultaneous Photoacoustic Volumetric Imaging and Spectroscopic Analysis.

ACS sensors·2021

Same author

Ultrasonic signal detection based on Fabry-Perot cavity sensor.

Visual computing for industry, biomedicine, and art·2021

A new phase-sensitive surface plasmon resonance (pSPR) biosensor uses differential phase measurement for enhanced performance. This novel biosensor achieves an ultra-wide dynamic range and high sensitivity for refractive index sensing.

Area of Science:

Optics and Photonics
Biosensing Technology
Surface Plasmon Resonance

Background:

Surface plasmon resonance (SPR) is a label-free technique for detecting biomolecular interactions.
Traditional SPR methods often face limitations in dynamic range and sensitivity.
Phase-sensitive SPR (pSPR) offers improved performance but requires further optimization.

Purpose of the Study:

To propose and investigate a novel phase-sensitive surface plasmon resonance (pSPR) biosensor.
To enhance the dynamic range and sensitivity of pSPR biosensing.
To utilize cylindrical vector beams for advanced SPR measurements.

Main Methods:

Development of a pSPR biosensor utilizing differential phase measurement.
Employing radially and azimuthally polarized cylindrical vector beams.

More Related Videos

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Published on: May 16, 2022

Related Experiment Videos

Last Updated: May 21, 2026

Mechanical Mapping of Spheroids Using Brillouin Spectroscopy

Mechanical Mapping of Spheroids Using Brillouin Spectroscopy

Published on: December 12, 2025

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Published on: May 16, 2022

Utilizing an inverted microscope with a total internal reflection fluorescence microscopic objective.

Main Results:

Achieved an ultra-wide dynamic range of 0.41 refractive index unit (RIU), significantly exceeding previous ATR pSPR sensors.
Demonstrated high sensitivity of ±9.05×10(-8) RIU/degree.
Maintained high imaging resolution and sensitivity simultaneously.

Conclusions:

The proposed pSPR biosensor offers a significantly wider dynamic range compared to conventional methods.
The differential phase measurement technique with cylindrical vector beams enables simultaneous high sensitivity and wide dynamic range.
This novel approach advances the capabilities of SPR biosensing for various applications.