Risk factors associated with ischemic heart disease occurence in acute ischemic stroke patients

Michal Kovacik1, Stefan Madarasz, Michal Kral

  • 1Comprehensive Stroke Centre, Department of Neurology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic. michal22kovacik@gmail.com

Insights

Age and arterial hypertension are key risk factors for ischemic heart disease (IHD) in patients who have had an ischemic stroke (IS). Identifying these factors aids in stratifying IS patients for IHD detection and management.

Area of Science:

  • Cardiology
  • Neurology
  • Public Health

Background:

  • Ischemic heart disease (IHD) poses a significant mortality risk for ischemic stroke (IS) patients.
  • Not all IS patients receive IHD screening.
  • Identifying specific risk factors for IHD in IS patients is crucial for risk stratification.

Purpose of the Study:

  • To identify exclusive risk factors (RFs) associated with IHD occurrence in IS patients.
  • To aid in stratifying IS patients for IHD detection.

Main Methods:

  • Retrospective, single-center study of 192 IS patients.
  • Patients divided into two subgroups: with and without IHD.
  • Logistic regression analysis used to evaluate risk factors including age, sex, arterial hypertension, atrial fibrillation, diabetes mellitus, lipid profiles, BMI, and carotid plaques.

Main Results:

  • Age (OR=1.109) and arterial hypertension (OR=6.298) were exclusively and significantly associated with IHD in IS patients.
  • P-values for age and arterial hypertension were P=0.001 and P=0.003, respectively.

Conclusions:

  • Age and arterial hypertension are identified as exclusive risk factors for IHD in IS patients.
  • These findings can guide IHD screening and management strategies for IS survivors.
Abstract

Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...