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Short term anti-tubercular drug therapy and hepatic microsomal enzyme activity. Antipyrine metabolism as an index
A Hamide1, G Sivagnanam, R Raveendran
1Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry.
The Journal of the Association of Physicians of India
|September 1, 1990
Abstract:
The effect of short course chemotherapy on the drug metabolising capacity of the liver was studied in 7 newly diagnosed pulmonary tuberculosis patients, using antipyrine as a model drug. Antipyrine elimination half-life and plasma clearance rate were not significantly altered by 3 weeks of therapy. It is concluded that short course chemotherapy does not affect antipyrine metabolising enzyme activity.