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Serotonin 2A receptor gene (HTR2A) polymorphism in alcohol-dependent patients
Małgorzata Wrzosek1, Andrzej Jakubczyk, Michał Wrzosek
1Department of Pharmacogenomics, Medical University of Warsaw, Żwirki i Wigury 61, PL 02-091 Warszawa, Poland.
Background:
The serotonergic (5-HT) dysfunction has been frequently described in subjects with alcohol dependence (AD). In the present study, a potential relationship between T102C polymorphism in the 5-HT receptor subtype 2Agene (HTR2A) and alcohol dependence was examined.
Methods:
Genotypes were analyzed in 150 AD patients diagnosed with DSM-IV criteria and in 80 healthy controls.
Results:
The genetic analysis showed that the frequency of 102C allele and C102C genotype in AD subjects was significantly higher than in controls. Moreover, AD patients homozygous for C allele had significantly lower age at onset of alcohol problems than subjects having at least one T allele.
Conclusion:
The results suggest a potential role of the T102C HTR2A polymorphism in development of alcohol dependence.
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