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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Related Experiment Video

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Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

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Occupational rhinitis caused by concurrent sensitization to two different allergens.

¹Hôpital du Sacré-Coeur de Montréal, Medicine, 5400 boul. Gouin oust, Montreal, Quebec H4J 1C5, Canada. roberto.castano@umontreal.ca

Occupational Medicine (Oxford, England)

|June 5, 2012

Summary

This study reports the first case of occupational rhinitis (OR) caused by simultaneous exposure to wheat flour and guar gum. Prompt diagnosis and allergen avoidance led to symptom resolution in a food industry worker.

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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Area of Science:

Occupational Medicine
Allergology
Immunology

Background:

Occupational respiratory allergies are common in the food processing industry due to allergens like wheat flour and guar gum.
No prior reports exist detailing occupational rhinitis (OR) concurrently caused by two distinct workplace allergens.

Observation:

A case of OR is presented in a male food industry worker, mid-40s, with concurrent exposure to wheat flour and guar gum.
The patient exhibited positive skin prick test responses to both wheat and guar gum extracts, with significantly elevated total IgE levels.

Findings:

Nasal challenge tests with wheat flour and guar gum confirmed the diagnosis of OR, inducing immediate clinical reactions and reduced nasal volume.
Avoidance of wheat and guar gum exposure resulted in the gradual resolution of the patient's nasal symptoms.

Implications:

This case highlights the possibility of dual sensitization to unrelated allergens in occupational rhinitis.
Co-sensitization and cross-reactivity are potential mechanisms to consider in patients with work-related rhinitis symptoms.