Related Experiment Video
Updated: May 21, 2026
08:38
Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
Published on: August 28, 2013
Paraganglioma of prostatic origin
B Padilla-Fernández1, P Antúnez-Plaza, M F Lorenzo-Gómez
1Department of Urology, University Hospital of Salamanca, Salamanca, Spain.
Clinical Medicine Insights. Case Reports
|June 5, 2012
Summary
Prostatic paraganglioma, a rare tumor in adult males, was diagnosed in a 34-year-old patient presenting with perineal pain. Surgical resection led to a full recovery, highlighting the importance of considering this rare diagnosis.
Area of Science:
- Urology
- Endocrinology
- Oncology
Background:
- Paragangliomas are typically benign tumors originating from extra-adrenal chromaffin cells.
- Prostatic paraganglioma is exceptionally rare, with only 10 prior reported cases in adult literature.
Observation:
- A 34-year-old male presented with perineal pain and elevated urinary catecholamines.
- Imaging revealed a 9 cm pelvic mass near the prostate with moderate metabolic activity.
- Prostate biopsy indicated a neuroendocrine tumor, suspected to be prostatic paraganglioma.
Findings:
- Diagnostic workup included elevated catecholamines, PET-CT, and MIBG I-123 scintigraphy, ruling out metastases.
- Histopathological examination confirmed the diagnosis of prostatic paraganglioma.
- Radical prostatectomy with mass excision under adrenergic blockade was successfully performed.
Implications:
- Prostatic paraganglioma should be considered in the differential diagnosis of prostate tumors, especially in young males.
- Diagnosis relies on catecholamine levels, imaging (MIBG scintigraphy), and histopathology.
- Surgical resection under adrenergic blockade is the standard treatment; long-term follow-up is necessary to monitor for malignancy.
Related Concept Videos
01:20Disorders of the Male Reproductive System
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
01:16Accessory Glands of the Male Reproductive System
The accessory ducts involved in sperm maturation and transportation include the epididymides, vasa deferentia, ejaculatory ducts, and urethra. These ducts play a critical role in the maturation, storage, and transportation of sperm from the testes to the urethra, where it is then released during ejaculation.
The epididymis is a small, comma-shaped organ located at the back of each testicle. The epididymis can be divided into three main parts: the head, body, and tail. The head of the epididymis...
The epididymis is a small, comma-shaped organ located at the back of each testicle. The epididymis can be divided into three main parts: the head, body, and tail. The head of the epididymis...
01:27Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
01:18Cranial Part of Parasympathetic Division
The cranial part of the parasympathetic division plays a crucial role in regulating the visceral functions of the head and specific structures in the neck, thoracic, and abdominopelvic cavities. Preganglionic fibers of the parasympathetic division exit the brain through cranial nerves III (oculomotor), VII (facial), IX (glossopharyngeal), and X (vagus), delivering parasympathetic output to the respective visceral structures.
The vagus nerve (cranial nerve X) alone accounts for approximately 75...
The vagus nerve (cranial nerve X) alone accounts for approximately 75...