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Related Concept Videos

Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction. It is...

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Updated: May 21, 2026

Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

Nanofiber-modified surface directed cell migration and orientation in microsystem.

Xu Zhang, Xinghua Gao, Lei Jiang

    Biomicrofluidics
    |June 5, 2012
    PubMed
    Summary

    Researchers developed a simple method to pattern polydimethylsiloxane (PDMS) surfaces using nanofibers, enhancing stromal cell viability and migration. This technique shows potential for studying cell behavior in complex microscale environments.

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    Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

    Published on: October 13, 2019

    Area of Science:

    • Biomaterials Science
    • Cell Biology
    • Tissue Engineering

    Background:

    • Cell-surface interactions are vital for biological processes and regenerative medicine.
    • Developing methods to control cell behavior on patterned surfaces is crucial.
    • Polydimethylsiloxane (PDMS) is a common material in microfluidics and tissue engineering.

    Purpose of the Study:

    • To demonstrate a simple method for patterning PDMS surfaces using sacrificial electrospun polyvinyl pyrrolidone (PVP) nanofibers.
    • To investigate the effect of these patterned surfaces on stromal cell growth, viability, and migration.
    • To explore cell migration and orientation in microfluidic channels integrated with patterned PDMS surfaces.

    Main Methods:

    • Fabrication of patterned PDMS surfaces using sacrificial electrospinning of PVP nanofibers.
    • Culturing and observing stromal cells on the modified patterned surfaces.
    • Integration of patterned PDMS surfaces with microfluidic channels to create a microsystem.
    • Analysis of cell migration and orientation under combined spatial and surface patterning effects.

    Main Results:

    • Stromal cells exhibited good viability on the patterned PDMS surfaces.
    • Aligned nanofibers on the patterned surface promoted cell migration.
    • The microsystem, combining microfluidic channels and patterned surfaces, influenced complex cell orientation.
    • Both microscale spatial factors and surface patterns contributed to cell orientation.

    Conclusions:

    • A simple, fast, and effective method for patterning PDMS surfaces was established.
    • The patterned surfaces and microsystem show potential for controlling cell behavior.
    • This approach can be applied to study cell responses in complex microenvironments.
    • The findings support applications in regenerative medicine and tissue engineering.