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Gall-bladder perforation after long-term dapsone therapy.

A M Choy¹, C C Lang

¹Department of Surgery, Ninewells Hospital, Medical School, Dundee, Scotland, UK.

Journal of Internal Medicine

|October 1, 1990

Summary

This summary is machine-generated.

Dapsone therapy for dermatitis herpetiformis can cause rare, severe complications. A patient developed life-threatening cholecystitis and hemolytic anemia, a previously undescribed adverse effect.

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Area of Science:

Dermatology
Hematology
Gastroenterology

Background:

Dapsone is a long-term treatment for dermatitis herpetiformis.
Hematological abnormalities are known side effects of dapsone therapy.

Observation:

A 65-year-old man presented with acute abdominal pain and vomiting.
The patient had a 30-year history of dapsone therapy for dermatitis herpetiformis.

Findings:

Investigations revealed Heinz body hemolytic anemia.
Emergency laparotomy identified a perforated gallbladder with pigmented biliary calculi.
This case represents a previously undescribed complication of dapsone therapy.

Implications:

Highlights the potential for severe, uncharacterized adverse effects from long-term dapsone use.
Suggests the need for increased vigilance regarding gastrointestinal and hematological complications in patients on dapsone.
Underscores the importance of considering dapsone as a potential etiology for severe cholecystitis, even in the absence of prior reports.