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Related Experiment Videos

Insulin protects cognitive function in experimental stroke.

A J Strong1, J E Fairfield, E Monteiro

  • 1Neurosurgery Research Group, Institute of Psychiatry, London, United Kingdom.

Journal of Neurology, Neurosurgery, and Psychiatry
|October 1, 1990
PubMed
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Mildly lowering blood glucose with insulin in rats after stroke significantly improved working memory. This suggests a potential therapeutic strategy for stroke recovery by controlling glucose availability.

Area of Science:

  • Neuroscience
  • Ischemic Stroke Research
  • Metabolic Regulation

Background:

  • In vitro studies suggest restricting glucose to ischemic areas reduces neuronal loss.
  • The role of glucose availability in acute central nervous system ischemia needs further investigation in vivo.

Purpose of the Study:

  • To investigate if insulin-induced hypoglycemia improves behavioral outcomes in a rat stroke recovery model.
  • To assess the impact of controlled hypoglycemia on working memory after cerebral ischemia.

Main Methods:

  • Rats were trained on a maze task assessing working memory, underwent cerebral ischemia and reperfusion, and were treated with insulin (2.0 u/kg-1) to induce mild hypoglycemia (plasma glucose ≥ 3.1 mmol/L).
  • Behavioral testing was repeated 14 days post-ischemia to evaluate working memory function.

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Main Results:

  • Ischemic rats exhibited significant working memory impairment (p < 0.0001).
  • Insulin-treated ischemic rats showed no significant impairment, performing indistinguishably from control animals.

Conclusions:

  • Mild hypoglycemia, induced by insulin, provides significant neuroprotection in a rat stroke model.
  • This approach demonstrates potential clinical applicability for stroke treatment, improving functional recovery.