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Updated: May 21, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

Malaria: a haematological disease.

Karolina S Akinosoglou¹, Elena E Solomou, Charalambos A Gogos

¹Department of Internal Medicine, University Hospital of Patras, Rio, Greece. k.akinosoglou07@imperial.ac.uk

Hematology (Amsterdam, Netherlands)

|June 6, 2012

Summary

Severe malaria, caused by Plasmodium falciparum, leads to significant mortality. Key hematological issues like anemia and spleen complications require careful management for better patient outcomes.

Area of Science:

Tropical Medicine
Hematology
Infectious Diseases

Background:

Plasmodium falciparum malaria is a leading cause of death globally.
Hematological abnormalities are characteristic of malaria, influencing prognosis and patient monitoring.
These abnormalities include severe anemia, coagulation issues, white blood cell changes, and spleen involvement.

Purpose of the Study:

To review the hematological abnormalities associated with severe Plasmodium falciparum malaria.
To discuss the prognostic and follow-up implications of these hematological changes.
To highlight the importance of managing anemia, coagulation, white blood cell counts, and spleen complications.

Main Methods:

Literature review of hematological findings in severe malaria.

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Analysis of mechanisms contributing to anemia (parasite invasion, intravascular hemolysis, reduced erythropoiesis).

Discussion of coagulation pathway dysfunction and its clinical relevance.

Main Results:

Severe anemia is a critical complication, often managed with transfusions.
Hemorrhagic complications are uncommon despite thrombocytopenia and coagulation defects.
White blood cell count changes, though less pronounced, are significant indicators of disease severity and prognosis.
Spleen involvement is complex, with splenic rupture being a fatal risk.

Conclusions:

Hematological abnormalities are crucial indicators in severe malaria management.
Prompt recognition and management of anemia, coagulation disturbances, and spleen-related issues are vital.
Vigilance against splenic rupture is essential, even with prophylaxis and treatment.